Adaptive Changes in Alphavirus mRNA Translation Allowed Colonization of Vertebrate Hosts

See on Scoop.itVirology and Bioinformatics from

“Genetic, phylogenetic, and biochemical data presented here support an evolutionary scenario for the natural history of alphaviruses, in which the acquisition of DLP structure in their mRNAs probably allowed the colonization of vertebrate host and the consequent geographic expansion of some of these viruses worldwide.”


I have taught for some time now that the evolution of many mammalian viruses must have involved adaptation of originally (and sometimes still) insect-infecting agents – given that insects crawled out onto dry land quite a long time before vertebrates did.  This is a nice illustration of that.  Pity I don’t teach anymore B-(

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