ViroBlogy

See on Scoop.it – Virology and Bioinformatics from Virology.ca

“These data demonstrate that Ad35, Ad26, and Ad48, which utilize CD46 as their primary cellular receptor, induce significantly greater innate cytokine responses than Ad5, which uses the coxsackievirus and adenovirus receptor (CAR). These differences in innate triggering result in markedly different immunologic milieus for the subsequent generation of adaptive immune responses by these vaccine vectors.”

Important news for the vectored vaccine community in general, and for HIV vaccine in particular: Ad5 was the vehicle of choice; now it looks as though it shouldn’t be.

Adenovirus graphic courtesy of Russell Kightley Media

See on jvi.asm.org

Tags: adenovirus, env, gag, HIV, macaque, prime-boost, vaccine

This entry was posted on 24 August, 2012 at 11:49 and is filed under General Virology, HIV, Vaccines: General. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.