Archive for April 12th, 2013

Hepatitis A virus discovered to cloak itself in membranes hijacked from infected cells

12 April, 2013

See on Scoop.itVirology News

Viruses have historically been classified into one of two types – those with an outer lipid-containing envelope and those without an envelope.

Ed Rybicki‘s insight:

…and hep A steals membranes from liver cells to circulate as an enveloped particle(s) in blood. This is a fascinating find, and doubtless will be followed by similar for other viruses.

 

The commentary has some speculation as to how vacciens work, if antibodies can’t see the virus – but they forget the virus has to get INTO the host in the first place, and environmental forms are non-enveloped, AND that the vaccine may well elicit some degree of cell-mediated immunity, which would target infected cells displaying degraded protein on tehir surfaces via MHC I-type receptors.

See on medicalxpress.com

Mississauga Article: Making vaccine for new bird flu virus could be a challenge

12 April, 2013

See on Scoop.itVirology News

TORONTO — Making a vaccine to protect against the new bird flu virus that has emerged in eastern China could prove to be problematic, influenza experts acknowledged yesterday.

Ed Rybicki‘s insight:

"…clinical trials of vaccines made to protect against other viruses in the H7 family have shown the vaccines don’t induce much of an immune response, even when people are given what would be considered very large doses."

This is a little worrying – and possibly a spur to making universal vaccines!

See on www.mississauga.com